Micky van de Ven Brace Ends The Toffees' Unbeaten Streak at Brand New Stadium
The Dutch defender emerged as the initial defender to score twice in a English top-flight match for Tottenham since Jan Vertonghen in March 2013.
Key points
Micky Van de Ven nods home twice in first half
The home side's Jake O'Brien has goal ruled after VAR review
Senegalese midfielder nets third in 89th minute
The defeat is the Merseyside club's initial at Hill Dickinson Stadium
Micky van de Ven scored twice as Spurs prolonged their unbeaten run in away games in the top division and handed the Toffees their initial loss at their new home.
The Toffees were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after 133 years at the conclusion of the previous campaign.
But Tottenham's leader the Dutchman struck twice from corners in the first half to place their strong form at risk, and they were failed to mount a comeback before the midfielder - assisted by former Toffees attacker the Brazilian - headed home a final goal to put the game to bed.
Jake O'Brien thought he had levelled the scores a short while after the defender's opener, directing a powerful header past Guglielmo Vicario from an Everton corner.
Beto, in the meantime, failed to convert a number of chances, while Vicario made a succession of fine stops to ensure the London club went five away games without defeat in the English top flight.
But the video assistant referee intervened, advising Craig Pawson to review the goal on the screen and the official ruled that the winger and Iliman Ndiaye were in offside positions and had impeded with the Spurs keeper.
This victory elevates the manager's team into third place in the Premier League, a handful of points off north London rivals and table-toppers Arsenal.
Everton stay in 14th position and sit six points clear of the relegation zone.
Tottenham analysis: The defender excels in duties at each end of pitch
After a uninspiring weekday display in the Champions League against Monaco, where they managed a only two shots on goal, the manager opted for the French striker in attack instead of ex-Everton forward Richarlison.
The summer signing was unable to make much of an impact before being substituted for the substitute after an hour on the pitch, but it turns out he wasn't needed in the final outcome.
Defender Van de Ven transformed into an offensive threat to be feared.
Tottenham's first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur directing the ball back across the face of goal for an unmarked the defender to head home.
And Ven de Ven - filling in as skipper in the Argentine's unavailability - added his next goal in added time as he outjumped Jordan Pickford to head home.
The Dutchman was equally impressive in defensive duties, partnering well with his defensive colleague as the pair handled excellently with the 34 crosses thrown their way by the opposition.
Toffees breakdown: Toffees lacking striker's instinct
Everton's new home had been a fortress, but it appears the novelty may have faded somewhat and supporters flocked to the gates after the midfielder's third for Tottenham.
The break in the team's unbeaten home run won't be a massive concern for David Moyes, but their striker situation will be.
The forward and Thierno Barry - the Everton's two recognised centre-forwards - had scored only a single goal between them before the weekend's outing.
And they were unable to add to that poor tally on a damp and dreary night on in Liverpool.
The striker's form was epitomized when he chose to bicycle-kick a clear chance from near the goal, even with having space and time to reposition for a more conventional shot that would have tested Vicario.
The substitute, as well, was unable to make an impact after replacing Beto in the 65th minute.
It wasn't for a lack of chance. The majority of Everton's offensive moves came through Grealish and Ndiaye, who relentlessly delivered threatening balls into the Tottenham box.
What next for both teams?
Everton: Moyes' men travel to Sunderland in the Premier League on early November at 20:00 GMT.
Spurs: Spurs travel to St James' Park on Wednesday, 29 October for their next round Carabao Cup match against Newcastle.